Nurse Practitioner Salary in South Carolina (2026)

Worth knowing: South Carolina's collaborative agreement requirement for nurse practitioners (SC Code §40-33-34) is a defining feature of NP practice in SC that national NP-career surveys understate. SC is NOT a Full Practice Authority state — SC nurse practitioners must maintain a written collaborative practice agreement with a supervising physician for prescriptive authority + diagnostic + treatment privileges. This collaborative agreement requirement creates substantial structural overhead vs FPA states (OR/WA/NM/AK/CO/etc.) and limits independent NP-led clinic models. Senior SC NPs clear $118-190K TC at specialty levels but typically below FPA-state senior NP comp due to the collaborative requirement constraint. MUSC's APP integration is substantial despite the collaborative agreement requirement, with senior MUSC cardiology + oncology + transplant NPs clearing $125-190K TC. Prisma Health is the largest SC NP employer (~30K total health system, ~700+ APP). PsyPact membership (SC joined 2019) supports SC PMHNP telehealth across compact-state lines. MUSC College of Nursing DNP program is one of the top US DNP programs per US News. SC's 6.5% top bracket has modest impact on most NP comp (most senior NPs clear $115-190K, mostly below the 6.5% top bracket which catches mainly subspecialty CRNA + Director comp). SC has 0% income tax first bracket up to $3,460.