Software Engineer Salary in Missouri (2026)

Worth knowing: Cerner Corporation's acquisition by Oracle in June 2022 ($28.3B — the largest single tech deal in Missouri history by far) reshaped the KC tech market. Oracle Health (the renamed Cerner operating unit) maintains its ~12,000-employee North Kansas City campus as Oracle's healthcare-software flagship operation. Senior software engineers at Oracle Health earn $135-220K TC on clinical-data platform, EHR modernization, and AI-augmented clinical decision support work. Edward Jones IT operates a substantial ~3,500-employee technology organization at Maryland Heights, supporting the largest US broker-dealer branch network (~15,000 branches) — senior software engineers $130-200K TC. Centene IT (Clayton, Fortune 25) plus Boeing Defense, Space & Security (~14,000 STL employees including substantial defense-software engineering) round out the picture. Washington University in St. Louis + WashU School of Medicine research IT employs senior research-software engineers at academic-faculty scales with intersecting NIH-funded research roles. The 1% city earnings tax in St. Louis AND Kansas City applies to non-resident SE wages earned within city limits — senior engineers at Edward Jones HQ Maryland Heights (outside STL city limits) and at Oracle Health North Kansas City (outside KC city limits) avoid the 1% city tax; downtown STL or KC employers (smaller tech presence) hit the full 5.95% combined rate.