Healthcare

Pharmacist Salary in South Carolina (2026)

The average Pharmacist in South Carolina earns around $138,000/year. After taxes, your estimated take-home is $98,466/year ($8,206/month).

Take-Home Pay Breakdown

CategoryAmount
Annual Take-Home Pay
$98,466
Monthly Take-Home Pay
$8,206
Biweekly Take-Home Pay
$3,787
Hourly Take-Home Pay

based on 2,080 hrs/year

$47/hr
Federal Tax
$21,854
State Tax
$7,123
FICA Taxes
$10,557
Effective Tax Rate

total taxes ÷ gross salary

28.65%
Estimates only — not tax advice. · Full disclaimer →

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Pharmacist Salary Ranges in South Carolina

Entry Level (0–3 yrs)

$118,000

/year

See tax breakdown →

Mid Level (3–7 yrs)

$138,000

/year

See tax breakdown →

Senior Level (7+ yrs)

$168,000

/year

See tax breakdown →

Not all Pharmacists earn the same — not even close

South Carolina's pharmacist market is anchored by MUSC Charleston pharmacy services (academic medical center pharmacy with substantial inpatient + outpatient + specialty pharmacy), Prisma Health pharmacy (largest SC health system across 17 hospitals + outpatient pharmacy network), Roper St. Francis Healthcare Charleston pharmacy, Bon Secours St. Francis Greenville pharmacy, AnMed Anderson + Spartanburg Regional + McLeod Florence community pharmacy, plus Publix + Walgreens + CVS + Harris Teeter retail pharmacy networks, with USC College of Pharmacy Columbia + MUSC College of Pharmacy Charleston academic training.

Senior Clinical Pharmacist (Hospital)

$128,000–$165,000

MUSC + Prisma + Roper + Bon Secours ICU + ED + oncology clinical pharmacy specialty

Senior Specialty Pharmacist

$118,000–$155,000

MUSC Hollings Cancer specialty pharmacy · oncology + transplant + HIV + REMS specialty

Senior Pharmacy Manager (Hospital)

$130,000–$175,000

Hospital pharmacy operations leadership · SC health system inpatient pharmacy

Senior Pharmacy Informatics

$118,000–$170,000

Epic Willow + Cerner pharmacy informatics · SC health system pharmacy IT

Senior Retail Pharmacist (Publix / Walgreens)

$112,000–$140,000

Retail pharmacy manager · Publix + Walgreens + CVS + Harris Teeter · senior retail band

Senior Ambulatory Care / MTM

$115,000–$150,000

MUSC + Prisma + Roper ambulatory pharmacy · MTM + anticoagulation + diabetes clinics

Senior Compounding / IV Pharmacy

$112,000–$148,000

SC hospital + 503A + 503B compounding · sterile + non-sterile · USP 797/800 specialty

Mid-Career Pharmacist (3-7 yrs)

$105,000–$130,000

Functional staff pharmacist at SC health system · transitioning to senior band

New Grad PharmD (0-2 yrs)

$95,000–$120,000

USC College of Pharmacy + MUSC College of Pharmacy PharmD pipeline · entry band

PGY-1 / PGY-2 Residency

$48,000–$58,000

MUSC + Prisma + Roper + Bon Secours pharmacy residencies · pre-clinical specialty path

Worth knowing: South Carolina operates two AVMA-accredited PharmD-granting institutions — USC College of Pharmacy Columbia (founded 1925, ~140 PharmD students/yr, the largest SC pharmacy school) + MUSC College of Pharmacy Charleston (founded 1881 as one of the oldest US pharmacy schools, ~85 PharmD students/yr) — and the dual-school pipeline supports the substantial SC retail + hospital + ambulatory pharmacy workforce that national pharmacist-career surveys understate. USC College of Pharmacy + MUSC College of Pharmacy combined graduate ~225 PharmDs/yr, supporting SC's pharmacy practice across Prisma Health + MUSC + Roper + Bon Secours health systems plus substantial retail pharmacy at Publix + Walgreens + CVS + Harris Teeter. MUSC Hollings Cancer Center pharmacy operates substantial oncology specialty pharmacy supporting MUSC's NCI-designated cancer center (the only NCI center in SC) — substantial chemotherapy + immunotherapy + cellular therapy pharmacy practice at academic medical center scale supporting senior specialty pharmacists at $118-155K TC. Publix Super Markets (the country's largest employee-owned supermarket chain with ~290 SC locations) operates substantial SC retail pharmacy — Publix's distinctive employee-ownership culture supports retail pharmacist retention. SC's 6.5% top bracket has limited impact on most pharmacist comp (most senior pharmacist comp lands $112-175K range below the top bracket). SC has 0% income tax up to $3,460 first bracket + RTW since 1954.

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