Data Scientist Salary in Missouri (2026)
Average Data Scientist pay in Missouri
$100,880/year
≈ $49/hour before tax
After tax (single filer)
$76,026/year
$6,336/month · effective tax rate 24.64%
- Federal $13,364
- State $3,773
- FICA $7,717
- Take-home
Pay by role in Missouri
- Principal ML Engineer / Lead Scientist$225,000–$340,000 TC
- Senior Data Scientist (Healthcare)$165,000–$235,000
- Senior Data Scientist (Insurance)$140,000–$200,000
- Senior Data Scientist (Financial)$135,000–$185,000
- Data Scientist (Mid-Level, 3-6 yrs)$95,000–$145,000
- ML Engineer / MLOps$115,000–$200,000
See the full tax breakdown
| Category | Amount |
|---|---|
Annual Take-Home Pay | $76,026 |
Monthly Take-Home Pay | $6,336 |
Biweekly Take-Home Pay | $2,924 |
Hourly Take-Home Pay based on 2,080 hrs/year | $37/hr |
Federal Tax | $13,364 |
State Tax | $3,773 |
FICA Taxes | $7,717 |
Effective Tax Rate total taxes ÷ gross salary | 24.64% |
Not all Data Scientists earn the same — not even close
Missouri's data science market is anchored by Oracle Health (acquired Cerner June 2022 for $28.3B — North Kansas City, the country's largest clinical-data ML organization at scale), Centene HQ Clayton (Fortune 25 health insurance, ~25K Missouri employees, claims data ML + member analytics), Edward Jones IT analytics (Maryland Heights, ~3,500 IT staff supporting branch network), Washington University in St. Louis research data science (NIH-funded WashU SOM + university research IT), and Boeing Defense, Space & Security STL (substantial defense ML/AI engineering). Pure-tech ML at FAANG scale doesn't exist in MO.
Principal ML Engineer / Lead Scientist
$225,000–$340,000 TC
Oracle Health senior clinical ML · Centene principal data science · Boeing Defense senior AI/ML
Senior Data Scientist (Healthcare)
$165,000–$235,000
Oracle Health clinical data + EHR analytics · BJC research · WashU SOM research-funded ML
Senior Data Scientist (Insurance)
$140,000–$200,000
Centene claims + member analytics (largest single-state health insurance DS) · RGA actuarial ML
Senior Data Scientist (Financial)
$135,000–$185,000
Edward Jones FA analytics · Stifel quant research · Anheuser-Busch InBev US supply-chain
Data Scientist (Mid-Level, 3-6 yrs)
$95,000–$145,000
Most common Indianapolis-comparable mid-career band · post-MS Mizzou + WashU + UMKC
ML Engineer / MLOps
$115,000–$200,000
Production ML deployment · Oracle Health clinical pipelines · Centene real-time scoring
Biostatistician (Healthcare)
$110,000–$175,000
WashU SOM research · BJC research · clinical trials · FDA-validated workflows premium
Junior Data Scientist / Analyst
$70,000–$105,000
WashU Olin + Mizzou + UMKC + Missouri S&T pipeline · Oracle Health new-grad
Quant Analyst (Edward Jones / Stifel)
$125,000–$195,000
Edward Jones investment-strategy quant · Stifel sell-side equity research quantitative
Senior Research Scientist (Boeing AI)
$155,000–$245,000
Boeing Defense AI/ML R&D · classified-clearance work · senior IC + research-funded
Worth knowing: Oracle Health (legacy Cerner, ~12,000 KC-area employees) is the country's largest single-state concentration of clinical-data ML talent. Following the Oracle acquisition June 2022 ($28.3B, the largest single tech deal in MO history), Oracle Health has expanded clinical AI / EHR modernization / clinical decision support hiring at senior ML levels. Senior ML engineers $145-220K TC working on clinical data platforms, drug-discovery support, and AI-augmented EHR. Centene HQ Clayton operates the country's largest single-state health-insurance data science organization (~25K Missouri employees, ~500+ ML/DS staff). The 1% city earnings tax in St. Louis applies to Centene Clayton employees only if Clayton's address is within city limits — Centene HQ at Clayton MO sits in St. Louis County (NOT St. Louis city), so Centene employees face only Missouri's 4.7% top rate. Edward Jones HQ Maryland Heights is similarly outside STL city limits at 4.7%. Oracle Health North Kansas City sits in Clay County MO (outside KC city limits) — also 4.7%.
Sources & Methodology
- →IRS Rev. Proc. 2025-32 — 2026 federal brackets and standard deduction
- →IRS Notice 2025-67 — 2026 retirement-plan contribution limits
- →IRS Rev. Proc. 2025-19 — 2026 HSA contribution limits
- →Social Security Administration — 2026 Social Security wage base
- →Missouri DOR Form MO-1040ES 2026 - tax rate chart and Missouri standard deduction amounts
- →BLS Occupational Employment and Wage Statistics — Data Scientist wage data for Missouri
Salary figures are market estimates for Data Scientists in Missouri and vary by employer, specialty, seniority, and metro. Take-home math assumes a single filer with no dependents, the standard deduction, and Missouri 2026 state rates. Local taxes, insurance premiums, and pre-tax contributions will move your number — run the calculator for your own situation.
Run your own numbers
- Missouri paycheck calculator → · 401(k), HSA, dependents
- RSU calculator → · flat 22% withholding often falls short
- Bonus calculator → · year-end, sign-on, retention
- Capital-gains calculator → · long-term rates, NIIT, state tax
Frequently Asked Questions
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More on Missouri
Salaries by profession, top-paying roles by industry, and an economic breakdown for Missouri in 2026.
Tax brackets, standard deductions, and take-home estimates for Missouri in 2026.
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