Data Scientist Salary in Missouri (2026)
The average Data Scientist in Missouri earns around $145,000/year. After taxes, your estimated take-home is $104,731/year ($8,728/month).
Take-Home Pay Breakdown
| Category | Amount |
|---|---|
Annual Take-Home Pay | $104,731 |
Monthly Take-Home Pay | $8,728 |
Biweekly Take-Home Pay | $4,028 |
Hourly Take-Home Pay based on 2,080 hrs/year | $50/hr |
Federal Tax | $23,534 |
State Tax | $5,643 |
FICA Taxes | $11,093 |
Effective Tax Rate total taxes ÷ gross salary | 27.77% |
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Read the guideData Scientist Salary Ranges in Missouri
Not all Data Scientists earn the same — not even close
Missouri's data science market is anchored by Oracle Health (acquired Cerner June 2022 for $28.3B — North Kansas City, the country's largest clinical-data ML organization at scale), Centene HQ Clayton (Fortune 25 health insurance, ~25K Missouri employees, claims data ML + member analytics), Edward Jones IT analytics (Maryland Heights, ~3,500 IT staff supporting branch network), Washington University in St. Louis research data science (NIH-funded WashU SOM + university research IT), and Boeing Defense, Space & Security STL (substantial defense ML/AI engineering). Pure-tech ML at FAANG scale doesn't exist in MO.
Principal ML Engineer / Lead Scientist
$225,000–$340,000 TC
Oracle Health senior clinical ML · Centene principal data science · Boeing Defense senior AI/ML
Senior Data Scientist (Healthcare)
$165,000–$235,000
Oracle Health clinical data + EHR analytics · BJC research · WashU SOM research-funded ML
Senior Data Scientist (Insurance)
$140,000–$200,000
Centene claims + member analytics (largest single-state health insurance DS) · RGA actuarial ML
Senior Data Scientist (Financial)
$135,000–$185,000
Edward Jones FA analytics · Stifel quant research · Anheuser-Busch InBev US supply-chain
Data Scientist (Mid-Level, 3-6 yrs)
$95,000–$145,000
Most common Indianapolis-comparable mid-career band · post-MS Mizzou + WashU + UMKC
ML Engineer / MLOps
$115,000–$200,000
Production ML deployment · Oracle Health clinical pipelines · Centene real-time scoring
Biostatistician (Healthcare)
$110,000–$175,000
WashU SOM research · BJC research · clinical trials · FDA-validated workflows premium
Junior Data Scientist / Analyst
$70,000–$105,000
WashU Olin + Mizzou + UMKC + Missouri S&T pipeline · Oracle Health new-grad
Quant Analyst (Edward Jones / Stifel)
$125,000–$195,000
Edward Jones investment-strategy quant · Stifel sell-side equity research quantitative
Senior Research Scientist (Boeing AI)
$155,000–$245,000
Boeing Defense AI/ML R&D · classified-clearance work · senior IC + research-funded
Worth knowing: Oracle Health (legacy Cerner, ~12,000 KC-area employees) is the country's largest single-state concentration of clinical-data ML talent. Following the Oracle acquisition June 2022 ($28.3B, the largest single tech deal in MO history), Oracle Health has expanded clinical AI / EHR modernization / clinical decision support hiring at senior ML levels. Senior ML engineers $145-220K TC working on clinical data platforms, drug-discovery support, and AI-augmented EHR. Centene HQ Clayton operates the country's largest single-state health-insurance data science organization (~25K Missouri employees, ~500+ ML/DS staff). The 1% city earnings tax in St. Louis applies to Centene Clayton employees only if Clayton's address is within city limits — Centene HQ at Clayton MO sits in St. Louis County (NOT St. Louis city), so Centene employees face only 4.95% state combined. Edward Jones HQ Maryland Heights similarly outside STL city limits at 4.95% combined. Oracle Health North Kansas City sits in Clay County MO (outside KC city limits) — also 4.95% combined.
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More on Missouri
Salaries by profession, top-paying roles by industry, and an economic breakdown for Missouri in 2026.
Tax brackets, standard deductions, and take-home estimates for Missouri in 2026.
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