How much does a Pharmacist make in South Dakota?

The average Pharmacist salary in South Dakota is around $138,000 per year. After federal taxes, FICA, and South Dakota state taxes, your estimated take-home pay is approximately $105,589 annually ($8,799/month).

What is the take-home pay for a Pharmacist in South Dakota?

On a $138,000 salary in South Dakota, your take-home pay is approximately $105,589/year or $8,799/month. Federal tax: $21,854. State tax: $0. FICA: $0.00.

Is $138,000 a good Pharmacist salary?

$138,000 is a strong salary for a Pharmacist — above the national median. In South Dakota, demand for this role is active.

How do South Dakota taxes affect Pharmacist salaries?

South Dakota levies state income tax on top of federal taxes. Your estimated state tax on $138,000 is $0. Your total effective tax rate is approximately 23.5%.

What are the career growth prospects for Pharmacists?

3% growth through 2032 (about as fast as average). Related roles include: Clinical Pharmacist, Retail Pharmacist, Hospital Pharmacist, Pharmacy Technician.

How can a Pharmacist in South Dakota reduce their tax bill?

Maximize your 401(k) contribution ($24,500 in 2026) to reduce taxable income. An HSA ($4,400 single / $8,750 family) adds further pre-tax savings. These strategies can save thousands annually — use our calculator to see your exact savings.

Healthcare

Pharmacist Salary in South Dakota (2026)

The average Pharmacist in South Dakota earns around $138,000/year. After taxes, your estimated take-home is $105,589/year ($8,799/month).

Take-Home Pay Breakdown

Category	Amount
Annual Take-Home Pay	$105,589
Monthly Take-Home Pay	$8,799
Biweekly Take-Home Pay	$4,061
Hourly Take-Home Pay based on 2,080 hrs/year	$51/hr
Federal Tax	$21,854
State Tax	$0
FICA Taxes	$10,557
Effective Tax Rate total taxes ÷ gross salary	23.49%

Estimates only — not tax advice. · Full disclaimer →

Want to model 401(k), HSA, or pre-tax contributions against your full salary? Open the salary calculator →

Got a year-end bonus, sign-on, or retention payout? See the bonus calculator →

1099 contract work or side gigs? Self-employment tax adds 15.3% on top. Open the 1099 tax calculator →

Working overtime? The 2025 OBBBA deduction may save you up to $12,500 on federal tax. Open the No Tax on Overtime calculator →

Key terms:···

Pharmacist Salary Ranges in South Dakota

Entry Level (0–3 yrs)

$118,000

/year

See tax breakdown →

Mid Level (3–7 yrs)

$138,000

/year

See tax breakdown →

Senior Level (7+ yrs)

$168,000

/year

See tax breakdown →

Not all Pharmacists earn the same — not even close

South Dakota's pharmacy market is anchored by South Dakota State University College of Pharmacy & Allied Health Brookings (the only SD PharmD-granting institution + the substantial SDSU PharmD + the substantial SDSU College of Pharmacy clinical research), Sanford Health Pharmacy Network (largest SD-HQ multi-state + Sanford USD Medical Center Pharmacy + Sanford Children's Hospital Pharmacy + multi-state SD + ND + MN + IA pharmacy), Avera Health Pharmacy (Avera McKennan + Avera Heart + Avera Cancer Institute Pharmacy + the substantial Avera eCARE Pharmacy nationwide telemedicine pharmacy), Monument Health Rapid City Pharmacy, the substantial Indian Health Service IHS SD reservation pharmacy (Pine Ridge + Rosebud + Cheyenne River + Standing Rock IHS pharmacy + the substantial IHS Loan Repayment), the substantial SD retail pharmacy (Walgreens + CVS + Hy-Vee SD + Lewis Drug + Sanford Pharmacy retail), plus VA Sioux Falls + Fort Meade VA pharmacy.

Senior Clinical Pharmacist (Avera Cancer Institute)

$135,000–$185,000+ bonus

Avera Cancer Institute · the substantial SD oncology pharmacy

Senior Clinical Pharmacist (Sanford / Avera)

$118,000–$162,000+ bonus

Sanford USD + Avera McKennan + Monument Health · acute clinical pharmacy

Senior Pharmacy Owner / Independent

$145,000–$258,000+ profit

Independent retail pharmacy owner · the substantial SD rural pharmacy + Lewis Drug legacy

Senior Pharmacist (Walgreens / CVS / Hy-Vee)

$112,000–$148,000+ bonus

Retail pharmacy · Walgreens + CVS + Hy-Vee + Lewis Drug + Sanford Pharmacy retail

Senior Avera eCARE Telemedicine Pharmacist

$115,000–$152,000+ bonus

Avera eCARE Pharmacy · the substantial Avera nationwide telemedicine pharmacy

Senior IHS Reservation Pharmacist

$118,000–$155,000+ loan repayment

Pine Ridge + Rosebud + Cheyenne River + Standing Rock IHS · NHSC + LRP

Senior Hospital Pharmacist (Sanford Children)

$112,000–$148,000+ bonus

Sanford Children Hospital Sioux Falls · pediatric clinical pharmacy

Senior Federal Civilian (VA Sioux Falls)

$112,000–$152,000

VA Sioux Falls + Fort Meade + Hot Springs VA · GS-13/14 federal civilian pharmacy

Mid-Career Pharmacist (3-7 yrs)

$105,000–$135,000

Functional pharmacist at SD health systems · transitioning to senior band

New Pharmacist (PGY-1 / Staff)

$92,000–$118,000

New PharmD at Sanford + Avera + Monument PGY-1 + retail · entry band

Worth knowing: Avera eCARE Pharmacy + the substantial nationwide telemedicine pharmacy is one of the country's distinctive concentrated US single-state telepharmacy anchor and a feature most national pharmacy surveys understate for SD. Avera eCARE Pharmacy (the substantial Avera eCARE substantial nationwide telemedicine pharmacy + the substantial Avera eCARE Behavioral Health + ICU + ED telepharmacy + the substantial Avera eCARE rural pharmacy access + the substantial Avera eCARE post-2020 substantial telemedicine pharmacy growth + the substantial Avera Sioux Falls eCARE hub serving the substantial multi-state rural pharmacy access nationwide) supports distinctive SD telepharmacy. Senior Avera eCARE telemedicine pharmacists clear $115-152K+ bonus. SDSU College of Pharmacy Brookings as the only SD PharmD-granting institution. Sanford Health Pharmacy Network multi-state + Avera Cancer Institute oncology pharmacy + Monument Health Rapid City + the substantial Indian Health Service IHS SD reservation pharmacy with IHS Loan Repayment + the substantial SD retail pharmacy (Walgreens + CVS + Hy-Vee + Lewis Drug + Sanford Pharmacy retail) + VA Sioux Falls federal civilian. SD 0% state income tax + SD RTW since 1946 anchor the SD pharmacy proposition.

Calculate Your Exact Take-Home Pay

Add 401(k) contributions, HSA, dependents, and more to see your personalized take-home.

Open Full Calculator

Frequently Asked Questions

Find answers to common questions about your taxes and our calculator.

Compare Two States

See how income tax, take-home pay, and total tax burden differ between any two US states side by side.

State 1

State 2

Pharmacist Salary in Other States

Pharmacist Salary in California →Pharmacist Salary in Texas →Pharmacist Salary in New York →Pharmacist Salary in Florida →Pharmacist Salary in Washington →$138,000 salary in South Dakota →

More on South Dakota

All Professions in South Dakota →

Salaries by profession, top-paying roles by industry, and an economic breakdown for South Dakota in 2026.

South Dakota State Income Tax Guide →

Tax brackets, standard deductions, and take-home estimates for South Dakota in 2026.

South Dakota Paycheck Calculator →

Adjust filing status, 401(k) for your exact 2026 take-home in South Dakota.