AI / ML Engineer Salary in Indiana (2026)
The average AI / ML Engineer in Indiana earns around $220,000/year. After taxes, your estimated take-home is $157,472/year ($13,123/month).
Take-Home Pay Breakdown
| Category | Amount |
|---|---|
Annual Take-Home Pay | $157,472 |
Monthly Take-Home Pay | $13,123 |
Biweekly Take-Home Pay | $6,057 |
Hourly Take-Home Pay based on 2,080 hrs/year | $76/hr |
Federal Tax | $41,704 |
State Tax | $6,015 |
FICA Taxes | $14,809 |
Effective Tax Rate total taxes ÷ gross salary | 28.42% |
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Read the guideAI / ML Engineer Salary Ranges in Indiana
Not all AI / ML Engineers earn the same — not even close
Indiana's AI/ML engineering market is anchored by Eli Lilly's substantial drug-discovery + clinical-data ML organization (post-GLP-1 success has substantially expanded Lilly's computational biology + AI-augmented research investment), Anthem/Elevance Health (Fortune 25, ~25K IN employees, largest single-state healthcare insurance AI/ML organization), Salesforce Tower Indianapolis (Marketing Cloud platform ML), Cummins Columbus (engine + power generation predictive maintenance), plus Crane Naval Surface Warfare Center cleared electronic warfare AI/ML (southern IN, ~3.7K employees) and Purdue + IU academic AI research.
Principal ML Engineer / Senior Scientist
$225,000–$385,000+ TC
Eli Lilly senior computational biology · Anthem senior data science · Purdue/IU industry-funded research
Senior ML Engineer (Pharma / Drug Discovery)
$175,000–$285,000
Eli Lilly drug-discovery ML · computational biology + protein folding · pharma-ML compliance premium
Senior ML Engineer (Healthcare Insurance)
$145,000–$220,000
Anthem/Elevance claims + member analytics · OneAmerica risk · HIPAA + actuarial ML specialty
Senior ML Engineer (Industrial / OT)
$135,000–$210,000
Cummins predictive maintenance · Allison Transmission · Subaru SIA · industrial OT/IT ML
Senior ML Engineer (SaaS / Commercial)
$145,000–$220,000
Salesforce Tower Marketing Cloud ML · Genesys · senior IC at IN tech employers
Senior MLOps Engineer
$125,000–$190,000
Production ML deployment · Lilly clinical-data pipelines · Anthem real-time scoring · senior platform IC
ML Engineer (Mid-Level, 3-6 yrs)
$108,000–$165,000
Most common mid-career band · Purdue + IU + Notre Dame + Rose-Hulman pipeline · cross-industry
Junior ML Engineer (0-3 yrs)
$85,000–$125,000
Post-Purdue + IU + Notre Dame + Rose-Hulman MS/PhD · Lilly LIRA + Anthem new-grad program · entry band
Senior Cleared ML Engineer (Crane NSWC)
$155,000–$245,000
Crane Naval Surface Warfare · cleared electronic warfare ML + signals processing · TS/SCI premium
Senior Research Scientist (Purdue / IU)
$155,000–$245,000
Industry-funded academic research · Purdue ML + AI faculty · IU Luddy School senior research
Worth knowing: Eli Lilly's drug-discovery + clinical-data ML organization is the structural depth feature most national AI/ML-career surveys understate for IN. Following the GLP-1 commercial success (Mounjaro + Zepbound have driven Lilly's revenue from $28B in 2022 to projected $50B+ in 2026), Lilly has substantially expanded computational biology + protein folding + clinical-trial AI investment — senior pharma ML engineers at Lilly clear $175-285K TC plus equity. Lilly's Indianapolis Technology Center hosts substantial computational biology + AI-augmented research operations. Anthem/Elevance Health (Fortune 25, ~25K IN employees) operates the country's largest single-state healthcare insurance AI/ML organization across claims analytics, member outcomes, fraud detection, and provider-network optimization. Crane Naval Surface Warfare Center (southern IN, ~3.7K employees) drives cleared electronic warfare + signals processing AI/ML at TS/SCI clearance scales — distinctive vs the DC/MD/NoVa cleared cluster. Purdue's Computer Science + Statistics + Industrial Engineering programs feed substantial AI/ML talent into Lilly + Anthem + Crane + national pure-AI firms. IN's 2.95% flat + Marion County 2.02% piggyback (4.97% combined effective) is among the lower US senior-AI state burden — substantially better than CA + NY + MA at senior IC tier.
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More on Indiana
Salaries by profession, top-paying roles by industry, and an economic breakdown for Indiana in 2026.
Tax brackets, standard deductions, and take-home estimates for Indiana in 2026.
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